Pharmacology of Cytokines
A. Mantovani, C. A. Dinarello, and P. Ghezzi
Price: £80.00 (paper)
ISBN-13: 978-0-19-850042-1
Publication date: 7 September 2000
344 pages, 1 plate, 42 line illus, 240x168 mm
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Ordering |
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| Reviews |
| - '"This book provides a 'breath of fresh air' in an otherwise complicated area of Immunology. In conclusion the authors have managed to produce a concise, well researched and well organised book, which lives up to its aims, in doing so it provides a useful review of research efforts in cytokine pharmacology, as such the book is suitable for clinicians, research scientists and students of
Immunology interested in cytokine pharmacology."Immunology News' -
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| Description | | - First comprehensive review of cytokine pharmacology
- Written by leading authorities in the field
- Extremely active area of research in academia and pharmaceutical industry
- Book overviews novel approaches to therapy using natural cytokine antagonists
- Covers basic science through to clinical development
| Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as
rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research.
The pharmacology of cytokines is an exploding area which is entering the clinical arena. This book gives an overview of cytokine research and
describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology of cytokines, the book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products . In addition to examining individual agents and approaches, it reviews the
pathophysiology of individual body systems and analysis specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control. |
Readership: Graduate students and researchers in immunology, both in academia and more importantly in the pharmaceutical industry.
| Contents |
Preface
Abbreviations
1.
Cytokines: a world apart?
Part 1 Pharmacology
2.
Inhibitors of cytokine production and action
3.
Inhibitors of cytokine processing
4.
Receptor antagonists
5.
Antibodies and soluble receptors
6.
Anti-inflammatory/immunosupressive cytokines
7.
Pharmacology of chemokines
Part II Pharmacology in a context
8.
Nervous System
9.
Cardiovascular system
10.
Cancer
11.
Liver and lung
12.
Skin
13.
Septic shock
Appendix: Mechanisms of action and clinical uses of Type I interferons
Index
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| Authors, editors,
and contributors |
A. Mantovani, Head, Department of Immunology and Cell Biology, Istituto Mario Negri, Milan; Chair of General Pathology, University of Brescia,
C. A. Dinarello, Head, Division of Infectious Diseases, University of Colorado Health Science Center, and
P. Ghezzi, Head, Laboratory of Neuroimmunology, Istituto Mario Negri, Milan
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