| Reviews |
| - '"This book is another cracker from the Oxford Chemistry Primers stable that again succeeds by breaking the mould of existing books in the area". Education in Chemistry, January 2003.' -
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| Description | | - Introduces the concept of protecting group devices. Good mechanistic framework.
- Grouping is by cleavage conditions, not by functional group, so that protecting groups are not dealt with in isolation.
- Temporary protecting groups: Highlights in situ methods where the protected molecule is never actually isolated.
| | Protecting Group Chemistry
provides an overview of the general methods that are used to block the reactivity of - i.e. protect
- specific functional grops thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting group strategy, relevant aspects of functional group reactivity, temporary protection, and introduces
the concept of protecting group devices
as an aid to unifying the wide range of available methods. The rest of the book is divided on the basis of broad classes of the experimental conditions that lead to cleavage of each protecting group (acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a
connection between the fundamental mechanisms of organic chemsitry - ionisation, substitution, addition, elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.
|
Readership: This Primer will support undergraduate courses on organic synthesis and advanced undergraduate/graduate courses on protecting groups.
| Contents |
1.
Introduction
2.
Acid-labile protecting groups
3.
Nucleophile/base-labile protecting groups
4.
Silyl protecting groups
5.
Redox deprotection
Index
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| Authors, editors,
and contributors |
Jeremy Robertson, University Lecturer in Organic Chemistry and Fellow, Brasenose College, Oxford
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