TEXTBOOK
Transcription Regulation in Prokaryotes
Rolf Wagner
Price: £45.00 (paper)
ISBN-13: 978-0-19-850354-5
Publication date: 18 May 2000
384 pages, 100 line illus, 234x156 mm
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| Reviews |
| - '"I therefore regard this book as a standard, extremely suitable not only for teaching to 3rd or 4th year undergraduate students with interest in cellular biology and molecular microbiology, but also for senior scientists who have research interests in prokaryotic transcription regulation2 Cell Biology International' -
- ''a superb, compact yet comprehensive, treatise on the regulation of gene expression, principally but not exclusively, in E.Coli and its phage ... A must for all students at undergraduate or postgraduate level and also for reseachers of eukaryotic transcription who need reminding of a few paradigms' Aslib' -
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| Description | | - Summarizes the field of prokaryotic transcription regulation, including up-to-the minute data
- Written by an authority in the field, taking an interdisciplinary approach with a biophysics emphasis
- Considers prokaryotic transcription regulation as a highly dynamic process
- Provides the fundamentals on which an understanding of eukaryotic regulation can be built
- Includes a comparative chapter for parallel and divergent mechanisms in prokaryotic and eukaryotic transcription regulation
| Transcription is part of the process of gene expression and is very different in prokaryotes and eukaryotes. In prokaryotic cells the synthesis reactions of DNA, RNA and proteins are intricately coupled as there are no subcellular compartments. Thus replication, transcription and translation occur simultaneously without local separation and the regulations of each is inter-related. In bacteria,
regulation is most important at the transcription stage of the biosynthetic process, and changes in the transcriptional efficiency account for major differences in the frequency of RNA formation and gene expression. This textbook has been written by an authority in the field for advanced students and postgraduates. Both clear and concise, there is an emphasis on transcription in bacterial and
phage expression systems, a key area of study and research in molecular biology. Many general mechanisms and principles emerge from studies of prokaryotic transcription complexes that help build an understanding of regulation in higher organisms.
Taking a biophysical approach, the text draws together elements of molecular biology, genetics, structural biology and biochemistry to provide an
invaluable summary of the field of prokaryotic transcription regulation for students in molecular biology and related areas of study such as microbiology and biotechnology.
Additional content information: this book includes
-new data on the composition and architecture of RNA polmerase
- new findings on sigma- and anti-sigma- factors
-a description of promoter elements underlining
the importance of upstream and downstream flanking sequences
-detailed kinetic description of the initiation process
-new data on the function of DNA curvature and topology on transcription
-general mechanisms of repression
-positive regulation
-termination, anti-termination and attenuation mechanisms
-implications of the nascent RNA structure in regulation
-stringent
control mechanisms and global networks
-comparative chapter for parallel and divergent mechanisms in prokaryotic and eukaryotic transcription regulation
-modern methods of analysis and new technical developments with selected examples |
Readership: Advanced undergraduates (and first year graduate students) on molecular biology and microbiology degree courses. Also students studying biotechnology and bacteriology courses.
| Contents |
1.
General Introduction
2.
The 'players' or cellular components necessary for transcription
3.
Initiation of transcription
4.
Transcription elongation
5.
Termination of transcription
6.
The role of DNA structure in transcription regulation
7.
Regulation by transcription factors
8.
Regulatory networks
Glossary
Index
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| Authors, editors,
and contributors |
Rolf Wagner, Heinrich-Heine University, Dusseldorf
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