Virus dynamics
Mathematical principles of immunology and virology
Martin A. Nowak and Robert May
Price: £39.95 (paper)
ISBN-13: 978-0-19-850417-7
Publication date: 23 November 2000
256 pages, 48 line illus, 234x156 mm
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| Reviews |
| - '... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host
' - Nature
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| Description | | - Theoretical immunology is an exciting and emerging field of study that has received considerable recent attention
- The first book to explore theoretical immunology in depth, by two leading scientists in the field
- Introduces mathematical ideas to biologists working in immunology and virology
- Describes the most current theoretical approaches to understanding HIV infection
- Accessible and well-written
| | We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding
like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various
circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more
widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book
concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. |
| Contents |
1.
Introduction: viruses, immunity, equations
2.
HIV
3.
The basic model of virus dynamics
4.
Anti-viral drug therapy
5.
Dynamics of hepatitis B virus
6.
Dynamics of immune responses
7.
How fast do immune responses eliminate infected cells?
8.
What is a quasispecies?
9.
The frequency of resistant mutant virus before anti-viral therapy
10.
Emergence of drug resistance
11.
Timing the emergence of resistance
12.
Simple antigenic variation
13.
Advanced antigenic variation
14.
Multiple epitopes
15.
Everything we know so far and beyond
Appendix A: Dynamics of resistance in different types of infected cells
Appendix B: Analysis of multiple epitope dynamics
References
Index
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| Authors, editors,
and contributors |
Martin A. Nowak, Head of Theoretical Biology Initiative, Institute for Advanced Study, Princeton and
Robert May, Royal Society Professor, University of Oxford
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and month of publication, was as accurate as
possible at the time the catalogue was compiled.
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