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Structure and Dynamics of Biomolecules
Neutron and Synchrotron Radiation for Condensed Matter Studies

Edited by Eric Fanchon, Erik Geissler, Jean-Louis Hodeau, Jean-René Regnard, and Peter A. Timmins

Price: £65.00 (paper)
ISBN-13: 978-0-19-850452-8
Publication date: 10 February 2000
444 pages, 18 color, 136 halftones & line illus, 240x168 mm
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Description
  • Contains vital information for HERCULES students
  • Covers synchrotron and neutron techniques
  • Very well illustrated containing over 150 figures
  • Each chapter written by an international authority
HERCULES is a course on the underlying principles and methods of neutron and synchrotron radiation techniques used in scientific research, constructed around laboratory practicals, tutorials and lectures and designed for biologists, chemists, geologists and physicists. This volume, the fourth in the HERCULES series, is the basis of the lecture course describing the theory and practice of techniques using either thermal neutrons or X- rays from a synchrotron source applied to the modern problems of biology. The themes treated are the crystallographic determination of protein structure, protein dynamics and partially ordered systems. A fourth section on more specialized topics includes spectroscopic techniques, X-ray microscopy, neutron spin polarization contrast methods and investigations of more complex molecules. Each chapter describes a different aspect of the subject, and the contributors are international authorities in their field. The book will be of use not only to beginners, but also, owing to the breadth of its scope, for experienced practitioners.

Contents
The plates section falls between pages 208-209
List of abbreviations
List of contributors
Protein structure
1. Challenges in structural molecular biology: genomics in three dimensions , J. Janin
2. Data collection and reduction methods , A. G. W. Leslie
3. Experimental determination of structure factors phases in biocrystallography , R. Fourme, et al.
4. Electron density - calculation, modification and interpretation , M. Kjeldgaard
5. Neutron crystallography of biological molecules , E. Pebay-Peyroula and D. Myles
6. Reactions in crystals and time-resolved crystallography , I. Schlichting
7. Local structure of metalloproteins at atomic resolution by XAFS , S. S. Hasnain
Dynamics of proteins
8. Molecular dynamics , M. J. Field
9. Inelastic and quasielastic neutron scattering: complementarity with biomolecular simulation , J. C. Smith
10. Diffuse X-ray scattering from molecular crystals , D. S. Moss, G. W. Harris, and A. Wostrack
Solutions and partially ordered systems
11. Small-angle X-ray scattering by solutions of biological macromolecules , P. Vachette and D. Svergun
12. Small angle neutron scattering , G. Zaccai
13. Structure and dynamics of biological membranes , G. Büldt, et al.
14. Fibre and muscle diffraction , J. M. Squire
Selected topics
15. Biological spectroscopy using low energy (VUV/UV) synchrotron radiation , G. R. Jones and I. H. Munro
16. X-ray microscopy , C. J. Buckley
17. Crystallography of viruses and very large macromolecules , D. I. Stuart, J. M. Grimes and E. E. Fry
18. The quest for high resolution phasing for large macromolecular assemblies exhibiting severe non-isomorphism, extreme beam sensitivity and no internal symmetry , A. Yonath
19. Nuclear spin contrast variation studies on macromolecular complexes , H. B. Stuhrmann
Index

Authors, editors, and contributors


Edited by Eric Fanchon, Institut de Biologie Structurale Jean Pierre Ebel,
Erik Geissler, laboratoire de Spectrometrie Physique,
Jean-Louis Hodeau, Laboratoire de Cristallographie, CNRS, Grenoble,
Jean-René Regnard, Universite Joseph Fourier de Grenoble I and CEA-Grenoble, and
Peter A. Timmins, Institut Laue Langevin, Grenoble


Links to web resources and related information
More in the same subject area:
Molecular biology
Biochemistry
Crystallography
Biophysics

The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.

 
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