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TEXTBOOK

Introduction to Protein Architecture
The Structural Biology of Proteins

Arthur M. Lesk

Price: £37.99 (paper)
ISBN-13: 978-0-19-850474-0
Publication date: 7 September 2000
360 pages, 213 color halftones, 70 color & 20 b/w line illus, 246x189 mm
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Reviews
  • 'This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The text should be considered for any introductory graduate level course in biochemistry.' -

Description
  • Superbly illustrated throughout with full colour computer-generated, scientifically accurate, 3-D effect images
  • Written in an accessible style by a leading expert in this field
  • Interesting and subtle exercises and problems at the ends of chapters
  • Introduces the reader to the use of the World Wide Web in bioinformatics end of chapter weblems introduce a new kind of WEB-based probLEM
Written in a clear and engaging style, and generously illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins.

The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics.

Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the vary great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).

To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.

Readership: Third-year undergraduates taking courses in Protein Structure and Function in biochemistry or molecular biology degrees. Enzymology 3rd year. First-year graduate students.

Contents
Chapter 1: The photosynthetic reaction centre: protein structure in a microcosm
The reaction centre from Rhodopseudomonas viridis
Conclusions
Chapter 2: In vivo, in vitro, in silicio
Why study proteins?
Protein structure and conformation
The known protein structures
The Protein Data Bank
The World Wide Web
Summary
Glossary
Chapter 3: Pattern and form in protein structure
Helices and sheets
The hierarchical nature of protein architecture
An album of small structures
Classification of protein structures
Loops
Protein-ligand interactions
Chapter 4: The varieties of protein structure
Catalogues of protein structure
The known structures
alpha-helical proteins
Beta-sheet proteins
alpha + Beta proteins
alpha / Beta proteins
Closed Beta-alpha-Beta barrel structures
Irregular structures
Conclusions
Chapter 5: Molecular evolution
Evolution of DNA and proteins
Evolution of protein structures
Structural relationships among related molecules
Chapter 6: Evolution in selected protein families
Evolution of the globins
Evolution of serine proteinases of the chymotrypsin family
NAD-binding domains of dehydrogenases
Chapter 7: Some proteins of the immune system
Antibody structure
Proteins of the Major Histocompatibility Complex
T-cell receptors
Chapter 8: Conformational changes in proteins
Structural changes arising from change in state of ligation
Hinge motions in proteins
The 'helix interface shear' mechanism of conformational change
The allosteric change in haemoglobin
Serpins: SERine Proteinase INhibitors
Higher-level structural changes
Appendix 1: An album for browsing
Appendix 2: Useful web sites

Authors, editors, and contributors


Arthur M. Lesk, Senior Research Associate, Department of Haematology, Cambridge Institute for Medical Research, Cambridge University


Links to web resources and related information
Preface


More in the same subject area:
Proteins

The specification in this catalogue, including without limitation price, format, extent, number of illustrations, and month of publication, was as accurate as possible at the time the catalogue was compiled. Occasionally, due to the nature of some contractual restrictions, we are unable to ship a specific product to a particular territory. Jacket images are provisional and liable to change before publication.

 
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