An all-in-one guide to stereological techniques
Quantitative Methods in Neuroscience
A Neuroanatomical Approach
Edited by Stephen M. Evans, Ann Marie Janson, and Jens Randel Nyengaard
Price: £88.00 (hardback)
ISBN-13: 978-0-19-850528-0
Publication date: 8 July 2004
332 pages, 4 maps, 11 halftones, 7 color & 60 line illus., 234x156 mm
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| Reviews |
| - 'The book is a practical tool for the increasingly large number of neuroscientists who require specific stereological techniques. It is both informative and valuable, in that it suggests appropriate methods and statistical treatments for resolving particular types of stereological problems.' - Physiology News, No 57
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| Description | | - The first book on stereological methods to be written for neuroscientists, allowing them to understand and implement quantitative methods in their research, as demanded by many scientific journals
- Limits discussion and formulae to focus on clear practical guidelines for applying these tools, allowing the neuroscientist with no prior experience to quickly understand the fundamentals of stereology
- Written by some of the international authorities on stereology, to provide a guide to the very latest and most reliable techniques
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Stereology is a valuable tool for neuroscientists, allowing them to obtain 3-Dimensional information from 2-Dimensional measurements made on appropriately sampled sections (usually obtained from histological sections or MRI/CT/PET scans). This 3-D information is invaluable in correlating structural/functional relationships in the pursuit of far greater understanding of the function of the
central nervous system. However, in carrying out such measurements, often based on limited data sets, there is a risk of experimenter bias. An important feature of modern design based stereology is to be aware of potential sources of bias and eliminate them during the data collection. With many of the major neuroscience journals now insisting that quantitative data be presented, there is a greater
need than ever for neuroscientists to understand the theory and practice behind quantitative methods, such as those offered by stereology.
Quantitative Methods in Neuroscience
is a cookbook of stereological methods written especially for neuroscientists. It provides clear and accessible advice about when and when not to use stereology. Throughout the book, the emphasis is on practical
guidance, rather than discussions and formulae. Written by leading scientists in the field of stereology, with a Foreword by D.C. Sterio, the book will be a valuable introduction to these methods for neuroscientists, and all those involved in development of new drug programmes.
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Readership: Neuroscientists doing quantitative studies; Scientists involved in drug development; Pathologists
| Contents |
1.
Introduction
,
Stephen M Evans & Jens Randel Nyengaard
2.
A case study from neuroscience involving stereology and multivariate analysis
,
Luis Cruz-Orive, A M Insausti, R Insausti & D Crespo
Number
3.
Introduction
,
Stephen M Evans & Jens Randel Nyengaard
4.
The use of fluorescent probes in cell counting procedures
,
Daniel A Peterson
5.
Counting in situ hybridized neurons
,
Bente Finsen, R Gregersen, E Lehrmann, S Lovmand & M J West
6.
Number - electron microscopy
,
Jens Randel Nyengaard, K-A Dorph-Petersen, Y Tang
7.
The number of microvessels estimated by an unbiased stereological method
,
Annemette Lokkegaard
Volume
8.
Introduction
,
Stephen M Evans & Jens Randel Nyengaard
9.
The nucleator and the planar and optical rotator applied in rat dorsal root ganglia
,
Trine Tandrup
10.
Estimation of number and volume of immunohistochemically stained neurons in complex brain regions
,
Karl-Anton Dorph-Petersen, Raben Rosenberg & Jens Rendel Nyengaard
Length
11.
Introduction
,
Stephen M Evans & Jens Randel Nyengaard
12.
Length estimation of nerve fibers in human white matter using IUR sections
,
Yong Tang & Jens Randel Nyengaard
13.
Virtual test systems for estimation of orientation dependent parameters in thick, arbitrary oriented sections
,
Jytte Overgaard Larsen, M vonEuler & Ann Marie Janson
14.
Spatial distribution
,
Stephen M Evans
Cell Culture
15.
Unbiased morphometrical techniques for the quantitative assessment of cells in primary dissociation cultures
,
Hannsjorg Schroder, Jens Rendel Nyengaard, W Selberis, E Lain, A Keller, C Kohler and B Witter
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| Authors, editors,
and contributors |
Edited by Stephen M. Evans, Hammersmith Imanet, Hammersmith Hospital, London,
Ann Marie Janson, Department of Neuroscience, Karolinska Institute, Stockholm, and
Jens Randel Nyengaard, Stereological Research Laboratory, Aarhus University Hospital
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The specification in this catalogue, including without
limitation price, format, extent, number of illustrations,
and month of publication, was as accurate as
possible at the time the catalogue was compiled.
Occasionally, due to the nature of some contractual restrictions, we
are unable to ship a specific product to a particular territory.
Jacket images are provisional and liable to change before publication.
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