From DNA Damage and Stress Signalling to Cell Death
Poly ADP-Ribosylation Reactions
Edited by Gilbert de Murcia and Sydney Shall
Price: £95.00 (hardback)
ISBN-13: 978-0-19-850633-1
Publication date: 23 November 2000
272 pages, 11 color plates, 46 halftones & line illus, 234x156 mm
|
Ordering |
Individual customers may:
order by phone, post, or fax.
Manufactured on Demand - stock will be supplied on a firm sale basis within 28 days
Teachers in UK and European schools (and FE colleges in
the UK):
|
| Reviews |
| - '"...well written and organized, and is equally useful for the experts and for scientists just entering this exciting and rapidly moving field."Trends in Genetics' -
|
| Description | | - Coverage of poly ADP-ribose polymerase biology and crystal structure
- Coverage of PARP homologues and inhibitors
- Role of PARP in cell death
| |
Over the last 10 years, it has become apparent that poly-ADP ribosylation reactions govern some of the fundamental processes of life. PARP 1 is a highly conserved enzyme and a constitutive factor of the DNA damage surveillance network and plays an essential role in the protection and processing of DNA ends as they arise in DNA damage, repair, and recombination. The recent discovery of multiple
members of the PARP family suggests an expanded role for poly-ADP ribosylation reactions. Poly ADP-ribosylation Reactions
contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its
homologues. A discussion of the novel pharmacological role of inhibition of PARP is also included. The final chapter outlines future directions in the field of cellular responses to DNA damage. Its comprehensive coverage of the multiple aspects of this type of post-translational modification induced by DNA damage mean this book will serve as reference for both new and experienced investigators.
|
| Contents |
Contributors
Abbreviations
1.
ADP-ribose polymer metabolism
2.
Poly (ADP-ribose) polymerase: structure and function
3.
Biological significance of poly (ADP-ribosylation) reactions: molecular and genetic approaches
4.
Poly (ADP-ribose) polymerase in cell death
5.
Activation of poly (ADP-ribose) polymerase in the pathogenesis of ischaemia-reperfusion injury
6.
New PARP inhibitors for radio- and chemotherapy of cancer
7.
Perspectives
Index
|
| Authors, editors,
and contributors |
Edited by Gilbert de Murcia, CNRS, Strasbourg and
Sydney Shall, Department of Molecular Medicine, King's College School of Medicine and Dentistry, London
|
The specification in this catalogue, including without
limitation price, format, extent, number of illustrations,
and month of publication, was as accurate as
possible at the time the catalogue was compiled.
Occasionally, due to the nature of some contractual restrictions, we
are unable to ship a specific product to a particular territory.
Jacket images are provisional and liable to change before publication.
|
VIEW BASKET
