Outline of Crystallography for Biologists
David Blow
Price: £39.95 (paper)
ISBN-13: 978-0-19-851051-2
Publication date: 11 April 2002
248 pages, 203 line, 32 halftones, 240x168 mm
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| Reviews |
| - 'I believe it should be on the bookshelves of every practising biological crystallographer ... Acta Crystallographica' -
- 'This book is a very timely contribution as it provides newcomers to the field of protein crystallography with a concise outline of the background of physics together with an overview of the practical aspects of protein structure determination by crystallography. David Blow is one of the grand masters of protein crystallography and has made any major contributions to the field...
Crystallography News' -
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| Description | | - Main text is non-mathematical making it accessible to all biological scientists.
- Mathematics contained in separate boxes to offer deeper insight to those who want it.
- Uses numerous illustrations to present ideas in a non-mathematical manner.
- BIOL08BIOS
- Examples show the application of ideas in research
- Emphasis is on measures of quality giving the reader a critical insight into research achievements.
| Outline of Crystallography for Biologists is intended for researchers and students in the biological sciences who require an insight into the methods of X-ray crystallography without needing to learn all the relevant theory. The main text is purely descriptive and is readable by those with minimal mathematical knowledge. Some mathematical detail is given throughout in boxes, but these can be
ignored. Theory is limited to the essentials required to comprehend issues of quality. There is an extensive reference section and suggestions for further reading for those who wish to delve deeper.
The first part 'Fundamentals' presents the underlying ideas which allow x-ray structure analysis to be carried out and provides an appropriate background to courses in structural
determination.
The second part 'Practice' gives more information about the procedures employed in the course of crystal structure determination. The emphasis is on the quality measures of X-ray diffraction analysis to give the reader a critical insight into the quality and accuracy of a structure determination and to enable the reader to appreciate which parts of a structure determination may
have caused special difficulty.
There is no pretence of completeness and many matters discussed in standard crystallography texts are deliberately omitted. However, issues not brought out in the standard texts are discussed, making it a useful resource for non-practising crystallographers as well.
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Readership: Researchers and students who require an insight into the methods of X-ray crystallography without needing to learn all the theory.
| Contents |
Preface
Introductory note
Part 1: Fundamentals
1.
Images and X-rays
2.
Crystals and symmetry
3.
Waves
4.
Diffraction
5.
Diffraction by crystals
Part II: Practice
6.
Intensity measurements
7.
Isomorphous replacement
8.
Anomalous scattering
9.
Molecular replacement
10.
Density-modification procedures: improving a calculated map before interpretation
11.
Electron-density maps
12.
Structural refinement
13.
Accuracy of the final model
References
Index
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| Authors, editors,
and contributors |
David Blow, Senior Research Fellow, Imperial College of Science, Technology, and Medicine (London)
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