| Reviews |
| - 'Any book that highlights the elegance of organic sythesis and gives a rational approach to the art will surely be welcomed with open arms; this is such a book.' - Chemistry in Britain, March 1996
- 'A gentle introduction to the subject' - Peter Budd, University of Manchester, New Scientist, March 1997
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| Description | | - Provides a logical, structured introduction to the principles of retrosynthetic analysis
- The only concise text on synthesis at this level
- Includes a table of common synthons
- Lists guidelines for efficient synthesis design
- Includes practice examples throughout the book
| | The ability to design effective syntheses is an essential skill for organic chemists. This valuable text uses a wide range of examples to teach students of chemistry how to adopt a logical and versatile approach to the design of synthetic routes. The concept of retrosynthetic analysis - a means for identifying simple starting materials for a synthesis - is first introduced with emphasis on the
importance of bond polarity and functional group interconversions. The next section describes how an effective route to a target molecule containing more than one functional group can be elucidated, and gives useful strategies to adopt when designing syntheses. Later chapters review methods for the control of chemo-, regio-, and stereoselectivity, and include a discussion of protecting groups.
Finally, four syntheses of the pyrrolidine alkaloids are compared and contrasted using the principles described in the book. Practice examples are provided throughout, making this concise text an invaluable study aid for all undergraduate chemists. |
Readership: Second-year undergraduate students of chemistry.
| Contents |
1.
Introduction to synthesis
2.
Retrosynthetic analysis I: The basic concepts
3.
Retrosynthetic analysis II: Latent polarity and FGIs
4.
Retrosynthetic analysis III: Strategy and planning in synthesis
5.
Selectivity I: Chemoselectivity and protecting groups
6.
Chemoselectivity II: Regioselectivity
7.
Chemoselectivity III: Stereoselectivity
8.
Selected organic synthesis
Glossary
Appendix: Synthon table
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| Authors, editors,
and contributors |
Christine L. Willis, Senior Lecturer in Chemistry, University of Bristol and
Martin Wills, Lecturer in Chemistry, University of Bath
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| Links to web resources and related information | More in the same subject area:
Organic chemistry
|
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