| Reviews |
| - 'The author's infectious enthusiasm as a teacher comes across on every page of this beautifully illustrated book. To guide her readers through this increasingly complex field, she introduces some novel features, including "Special interest" boxes, sections labelled "Pause and think", well-designed chapter highlights and aids to "Memory refreshment". Given the speed of development of this field,
the book is remarkably up to date.' - Sir David Weatherall, THES Textbook Guide No. 23, February 2006
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| Description | | - The first text to show how an understanding of the molecular processes underpinning cancer can be directly applied to the development of new therapeutics, giving students a clear appreciation of how the theory relates to real life scenarios
- Provides a carefully structured overview of the molecular mechanisms that regulate cell replication, and relates defects in these mechanisms to the onset of cancer, so that students can clearly see the link between the two
- Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student; clarity is not sacrificed to achieve a contemporary account of the field
- Online Resource Centre features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources
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Many of the cells in our body undergo tightly regulated replication to enable growth to occur, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and
mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
offers a fresh approach to the study of the molecular basis of cancer, and shows how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted
therapeutic agents.
Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being
applied to develop new targeted therapeutic strategies.
The Molecular Biology of Cancer
will prove a valuable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.
Companion Web Site
Features figures from the book available to download, to facilitate lecture preparation, and a web link library
to give students easy access to relevant online resources.
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Readership: Advanced undergraduates and beginning graduates on biochemistry, molecular cell biology, and biomedical-related programmes of study.
| Contents |
1.
Introduction
2.
DNA Stability: Mutations vs. Repair
3.
Genes, Chromatin, and Expression
4.
Growth Factors in Cell Proliferation
5.
Tumor Suppression
6.
Apoptosis
7.
Stem Cells and Differentiation
8.
Metastasis
9.
Nutrients, Hormones, and Gene Interactions
10.
Conclusions: Cancer in the Future?
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| Authors, editors,
and contributors |
Lauren Pecorino, Senior Lecturer and Biochemistry Programme Leader, School of Chemical and Life Sciences, University of Greenwich
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The specification in this catalogue, including without
limitation price, format, extent, number of illustrations,
and month of publication, was as accurate as
possible at the time the catalogue was compiled.
Occasionally, due to the nature of some contractual restrictions, we
are unable to ship a specific product to a particular territory.
Jacket images are provisional and liable to change before publication.
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