| Reviews |
| Review(s) from previous edition:
- '"There is excellent all-round coverage here for both undergraduates and postgraduate researchers ... This is a textbook which should be used throughout all medicinal chemistry courses."' - Chemistry & Industry 2002
- '"In summary Patrick is in my opinion the best text support for a Medicinal Chemistry programme and it continues to be better and better with each review..."' - Stuart Warriner, University of Leeds, 2004
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| Description | | - The lively, reader-friendly writing style makes a complex subject readily accessible to all students, regardless of ability
- An interdisciplinary treatment of medicinal chemistry assumes little background knowledge, making the book invaluable to a broad range of students
- Key points, an expanded glossary, further reading lists, and end of chapter questions all make the book an even more effective one to learn from
- Boxed examples which show how the concepts of medicinal chemistry underlie the development of modern drugs, illustrating how the theory of medicinal chemistry is applied in practice
- A new two-colour text design increases the clarity of figures, which greatly enhance the explanation of difficult concepts
- Online Resource Centre includes figures available to download, to facilitate lecture preparation, and 3D molecular structures plus multiple choice questions, to encourage and support independent learning
| New to this edition- New chapters on anti-cancer and anti-viral agents provide detailed case studies of the development of modern drugs
- Boxed examples draw students' attention to how the concepts of medicinal chemistry are applied in practice
- New key points, an expanded glossary, further reading lists, and new end of chapter questions all give improved support for student learning
- A new two-colour page design enlivens the text, and increases the clarity of the figures, which greatly enhance the explanation of difficult concepts
- Logical subdivision into four parts, facilitates the book's use by students with little prior understanding of the subject area
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Many of us think nothing of taking a painkiller to ease a headache, or to relieve the symptoms of 'flu. But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaging insight into the one field of chemistry that arguably has the greatest impact on our quality of life than
any other.
Newly structured into four parts, the book opens in Part A with an introduction to pharmacodynamics and pharmacokinetics. Pharmacodynamics considers the types of molecular targets used by drugs, the interactions which are involved when a drug meets that target, and the consequences of those interactions. Pharmacokinetics considers the issues involved in a drug reaching its target in
the first place. Part B goes on to examine the general principles and strategies involved in discovering and designing new drugs and developing them for the marketplace, while Part C looks at particular 'tools of the trade' which are invaluable in those processes. Finally, Part D covers a selection of specific topics within medicinal chemistry. Reflecting a change in emphasis in medicinal
chemistry research, this Part takes us from the largely trial-and-error approach to drug design to the rational approach, and explores the most recent advances in molecular biology and genetics which have revolutionised drug design.
With a striking new two-colour text design, and greatly enriched learning features, the third edition conveys the fascination of working in a field which overlaps
the disciplines of chemistry, biochemistry, physiology, microbiology, cell biology, and pharmacology. A must-have textbook for any student of medicinal chemistry.
Online Resource Centre
- Figures available to download, to facilitate lecture preparation
- 3D molecular structures, to enable students to visualise key structures in an interactive way
- Multiple choice questions with
answers, to support and encourage independent learning
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Readership: Undergraduate chemistry students taking core or optional modules in medicinal chemistry as part of a broad chemistry degree or more specialised medicinal or pharmaceutical chemistry programme. Also of interest to pharmacy students and postgraduates who have a basic grounding in chemistry and are interested in a future career in the pharmaceutical industry.
| Contents |
PART A
Pharmacodynamics and pharmacokinetics
1.
Drugs and the medicinal chemist
2.
The why and the wherefore - drug targets
3.
Proteins as drug targets
4.
Proteins as drug targets - enzymes
5.
Proteins as drug targets - receptors
6.
Proteins as drug targets - receptor structure and signal transduction
7.
Nucleic acids as drug targets
8.
Pharmacokinetics and related topics
PART B
Drug discovery, design and development
9.
Drug discovery - finding a lead
10.
Drug design - pharmacodynamics
11.
Drug design - pharmacokinetics
12.
Drug development
PART C
Tools of the trade
13.
Quantitative structure-activity relationships (QSAR)
14.
Combinatorial synthesis
15.
Computers in medicinal chemistry
PART D
Topics in medicinal chemistry
16.
Antibacterial agents
17.
Antiviral drugs
18.
Anticancer agents
19.
The peripheral nervous system - cholinergics, anticholinergics, and anticholinesterases
20.
The adrenergic nervous system
21.
The opium analgesics
22.
Anti-ulcer agents
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| Authors, editors,
and contributors |
Graham L. Patrick, Lecturer in Chemistry, Department of Chemistry, University of Paisley
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The specification in this catalogue, including without
limitation price, format, extent, number of illustrations,
and month of publication, was as accurate as
possible at the time the catalogue was compiled.
Occasionally, due to the nature of some contractual restrictions, we
are unable to ship a specific product to a particular territory.
Jacket images are provisional and liable to change before publication.
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