International Immunology

International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories throughout the world.

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Featured article - December issue

Tribbles 2 controls monocyte inflammation

In this article, Kiss-Toth and colleagues (p. 1543) show that tribbles 2 (trb-2) is a novel regulator in human monocytes, inhibiting ERK and JNK activation. The authors detail the molecular interactions with other mitogen-activated protein kinases; they also describe the effect of low-density lipoprotein and of IL-8 on trb-2 and the importance of this mechanism for regulating monocyte functions.